منابع مشابه
Complexity control in a mixture model by Hardy-Weinberg equilibrium
Amethod of complexity control in multinomial mixture modeling of multiple-marker genotype data, imposing the Hardy-Weinberg equilibrium (HWE) between the genotype values, is studied. This is a very natural restriction and known to hold at population level under modest assumptions. The hypothesis under study is that imposing this restriction will prevent overfitting and lead to a better model. T...
متن کاملA clarification of the Hardy-Weinberg law.
C. C. Li showed that Hardy-Weinberg proportions (HWP) can be maintained in a large population by nonrandom mating as well as random mating. In particular he gave the mating matrix for the symmetric case in the most general form possible. Thus Li showed that, once HWP are attained, the same proportions can be maintained by what he called pseudorandom mating. This article shows that, starting fro...
متن کاملF . Dove Hardy , Weinberg and Language Impediments
THE Hardy-Weinberg law is the cornerstone of dipalso, even more crucial, that Mendelism and Darwin’s loid population genetics. Yet it seems trivially obviidea of continuous evolution were compatible” (Proous, a routine application of the binomial theorem. And vine 1971, p. 85). Yule’s statement was a curious slip indeed it was so regarded by Hardy when he wrote his for a man who had introduced ...
متن کاملRe-imagining the Hardy-Weinberg Law
Under random mating, a progeny's alleles are independently sampled from the parental gene pools. Here is a new proof which avoids the usual algebraic complexity, based on a restated Mendel's First Law. Another simplified proof along the old approach led to the discovery that allelic independence can hold under random mating and fertility selection. The theoretical existence and number of such s...
متن کاملBayesian methods for examining Hardy-Weinberg equilibrium.
Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 1999
ISSN: 0003-4800,1469-1809
DOI: 10.1046/j.1469-1809.1999.6360535.x